Abstract: “In this study, the effect of charge which is brought about by the lipid composition and method of preparation on the properties of ferulic acid encapsulated liposomes was investigated to determine the optimum conditions with respect to mainly in vitro release and ex vivo skin permeation of ferulic acid. Positively charged liposomes exhibited higher encapsulation efficiencies than negatively charged liposomes. However, positively charged liposomes were much larger and less homogenous than negatively charged liposomes, which may influence many properties including biodistribution. It was revealed that positively charged liposomes are better for slow release while negatively charged liposomes are better for skin permeation properties.”

Keywords: liposomal encapsulation, ferulic acid, slow release, skin permeation