Abstract: “In Vietnam, there have been reported to be highly incident cancer of nasopharynx. Epstein-Barr virus (EBV) have been considered to be mainly associated with nasopharyngeal carcinoma (NPC), in which EBV-encoded latent protein 1, 2 (LMP-1, LMP2) were found to be important factor target to NPC development. Thus, it is important to explore whether a non-invasive method could be applicable to screen and early diagnosis of NPC. In current study, NP (nasopharyngeal) and non-NP brushing samples were collected consecutively from participants when they underwent NP biopsy at Cho Ray Hospital, HCMC, Vietnam. PCR assay were used to detection of LMP-1, LMP-2 and T-test statistical analysis were used to analyze its diagnosis value. NP-brushing samples from NPC patients showed frequency of 45.00% and 60.00% for LMP-1 and LMP-2, respectively. Conversely, none of any cases of non-NP brushing samples were found to be positive to target both/individual genes. Virtually, in combination of both two genes,”

Keywords: non-invasive, LMP-1, LMP-2, nasopharyngeal carcinoma, NP brushing sample, Vietnamese population